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After the Former U.S.A. …

was torn apart by the murderous post-Black Swan Conflicts, numerous warring rival regions were created. Because most airplanes were gone and ground vehicles very limited, regional borders tended to settle at natural boundaries like rivers and mountains. Meso is short for  Mesopotamia: the land in the middle of rivers. Where no government was created or none was desired live the Luddites who shun the frantic scramble for technology that consumes the major regions.